Joint Health is the result of Revolution Health & Wellness Clinic’s partnership with BiotanikaTM, a Canadian company that develops evidence-based natural health products for pain management. It is among a trio of formulas that also includes Inflam-Arrest and Inflam-X Gel. The formulation of Joint Health began with researchers at Biotanika investigating the potential of traditional herb extracts to act additively or synergistically to reduce inflammation and pain using the lowest doses of each herb. Biotanika used three pre-clinical test protocols that are recognized by the scientific community as good models for inflammatory diseases. These tests resulted in formulas benchmarked with current standards of care used in western medicine. The primary goal of the first clinical trial of the three formulas was to assess the safety and efficacy for the relief of pain in fourteen patients with either low back pain, joint (knee, shoulder, or hip) pain, or muscular or articular pain (the majority had moderate-to-severe pain). These patients had visited a natural health care practitioner seeking alternative therapies to NSAIDs or surgery. As is most often seen in patients scheduled for knee replacement surgery or who have had knee replacements, benefit was nil. However, all patients with low back, hip and shoulder pain demonstrated significant benefit.
Glucosamine Sulfate, a chondro-protective agent occurring naturally in all human tissues, appears to stimulate the manufacture of cartilage components and the deposition of sulfur into the cartilage. In combination with chondroitin sulfate it may be effective in patients with moderate-to-severe knee pain.[1,2,3]
Methylsulfonylmethane (MSM) is a naturally-occurring, sulfur-containing, water-soluble compound (AKADMSO2) has been demonstrated to possess anti-inflammatory and antioxidant properties.[4,5]
Chondroitin Sulfate, a primary proteoglycan in the body, attracts and retains a significant quantity of water guaranteeing cartilage resistance and elasticity. It has anti-inflammatory and antioxidative properties.[6,7] Hyaluronic Acid, a naturally occurring glycosaminoglycan in synovial fluid, helps create a viscous environment, cushion joints and maintains normal joint function. It has anti-inflammatory and antioxidant properties.[8,9]
Vitamin C and Manganese – Vitamin C is essential for synthesis of collagen and for maintaining its integrity. Manganese is important in the growth and development of normal bone and in the synthesis of cartilage. [10] Studies in rats, rabbits and humans have demonstrated a joint supportive, anti-inflammatory effect of a combination of glucosamine, chondroitin and manganese ascorbate. [11,12]
Vitamin E, in conjunction with Selenium plays an important role in protecting tissues against oxidative reactions. [13] Selenium limits oxidative stress affecting chondrocytes and synoviocytes in some chondral tissue diseases.
Directions
Take 2 capsules with each meal (6 capsules daily)
References
- Distler J, Anguelouch A. Evidence-based practice: review of clinical evidence on the efficacy of glucosamine and chondroitin in the treatment of osteoarthritis. J Am Acad Nurse Pract. 2006 Oct;18(10):487-93 [PMID: 16999714]
- Clegg DO, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med. 2006 Feb 23;354(8):795-808 [PMID: 16495392]
- Matheson AJ, Perry CM. Glucosamine: a review of its use in the management of osteoarthritis. Drugs Aging. 2003;20(14):1041-60 [PMID:14651444]
- Parcell S. Sulfur in human nutrition and applications in medicine. Altern Med Rev. 2002 Feb;7(1):22-44 [PMID: 11896744]
- Beilke MA, et al. Effects of dimethyl sulfoxide on the oxidative function of human neutrophils. J Lab Clin Med 1987, 110:91-96 [PMID:3598341]
- Chan PS, Glucosamine and chondroitin sulfate regulate gene expression and synthesis of nitric oxide and prostaglandin E(2) in articular cartilage explants. Osteoarthritis Cartilage. 2005 May;13(5):387-94 [PMID: 15882562]
- Ha BJ. Oxidative stress in ovariectomy menopause and role of chondroitin sulfate. Arch Pharm Res. 2004 Aug;27 (8):867-72 [PMID: 15460450]
- Campo GM, et al. Aromatic trap analysis of free radicals production in experimental collagen-induced arthritis in the rat: protective effect of glycosaminoglycans treatment. Free Radic Res. 2003 Mar;37(3):257-68.[PMID: 12688421]
- Campo GM, et al. Administration of hyaluronic acid and chondroitin-4-sulfate limits endogenous antioxidant depletion and reduces cell damage in experimental acute pancreatitis. Pancreas. 2004 Mar;28(2):E45-53. [PMID: 15028960]
- Strause L, Saltman P, Glowacki J.The effect of deficiencies of manganese and copper on osteoinduction and on resorption of bone particles in rats. Calcif Tissue Int. 1987 Sep;41(3):145-50. [PMID: 3117341]
- Beren J, Hill SL, Diener-West M, Rose NR Effect of pre-loading oral glucosamine HCl/chondroitin sulfate/manganese ascorbate combination on experimental arthritis in rats. Exp Biol Med (Maywood). 2001 Feb;226(2):144-51 [PMID: 11446439]
- Das A Jr, Hammad TA Efficacy of a combination of FCHG49 glucosamine hydrochloride, TRH122 low molecular weight sodium chondroitin sulfate and manganese ascorbate in the management of knee osteoarthritis. Osteoarthritis Cartilage. 2000 Sep;8(5):343-50 [PMID: 10966840] 13. Benoit C., [Intervention of the diet in the appearance of lameness in the foal] in French, PhD esis., Lyon, 1998
Caution
Joint Health is not suitable for people with allergies to fish or shellfish. Diabetics should consult their doctor before using this product. If you are pregnant or breast feeding; if you have or suspect you have a medical condition, or if you are taking prescription drugs consult a healthcare practitioner before use. Do not exceed the recommended daily intake. Do not use if security seal is broken. Keep out of reach of children. Store at room temperature.
