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September 10, 2025

Longevity Panel: Comprehensive Lab Testing for Healthspan and Prevention

Revolution Health’s Longevity Panel is a comprehensive Core Health Assessment measuring heart, hormone, thyroid, inflammation, and metabolic markers to optimize vitality and longevity.

Longevity Panel: Comprehensive Lab Testing for Healthspan and Prevention

The Longevity Panel: Your Comprehensive Guide to Optimizing Healthspan

Introduction

When it comes to optimizing long-term health, most annual check-ups and “basic” blood tests barely scratch the surface. They may catch obvious disease but often miss the early warning signs of cardiovascular disease, metabolic dysfunction, hormonal imbalance, thyroid disorders, and nutrient deficiencies—the very issues that shorten healthspan and reduce quality of life.

At Revolution Health, we’ve designed the Longevity Panel as the foundation of our Core Health Assessment. This comprehensive lab panel goes far beyond routine testing, measuring key biomarkers across cardiovascular health, hormones, thyroid function, inflammation, nutrition, and blood sugar regulation. By tracking these labs annually, we can identify hidden risks early, personalize prevention, and help you maintain optimal vitality for years to come.

Why the Longevity Panel Matters

  • Prevention First: Detects issues before they become chronic diseases.

  • Personalized Care: Identifies your unique hormonal, metabolic, and inflammatory patterns.

  • Performance & Vitality: Goes beyond disease screening to optimize energy, cognition, and longevity.

  • Holistic View: Integrates cardiovascular, endocrine, metabolic, and nutritional health into one panel.

What’s Included in the Longevity Panel

The Longevity Panel is divided into several key categories:

  1. Basic Cardiovascular Panel

  2. Advanced Cardiovascular Panel

  3. Metabolic Panel

  4. Thyroid Panel

  5. Male Hormone Panel

  6. Female Hormone Panel

Below, we’ll break down each group of labs, explaining what they measure and why they matter.

1. Basic Cardiovascular Panel

Heart disease remains the leading cause of death in the U.S., but most cardiovascular risk develops silently over years. These tests detect both traditional and advanced lipid markers, along with inflammation and oxidative stress signals that drive vascular disease.

  • Lipid Basic – Standard cholesterol panel measuring total cholesterol, LDL, HDL, and triglycerides.

  • Lipoprotein(a) [Lp(a)] – A genetic cholesterol marker linked to premature heart disease and stroke.

  • NMR Panel – Looks at LDL particle number and size, providing a more accurate cardiovascular risk assessment than standard cholesterol alone.

  • Small Dense LDL (sdLDL) – A highly atherogenic particle associated with insulin resistance and plaque formation.

  • Uric Acid – Elevated levels are linked not only to gout but also to metabolic syndrome and cardiovascular risk.

  • Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) – An enzyme tied to arterial wall inflammation and plaque instability.

  • Myeloperoxidase (MPO) – A marker of oxidative stress and vascular inflammation, predictive of acute coronary risk.

Why it matters: These labs give a 360-degree view of heart disease risk, catching issues that standard cholesterol tests overlook.

2. Advanced Cardiovascular Panel

For patients with risk factors, family history, or unexplained symptoms, advanced cardiovascular markers provide deeper insights.

  • BNP (B-type Natriuretic Peptide) – Measures heart strain; elevated levels may signal early heart failure risk.

  • ADMA/SDMA (Asymmetric and Symmetric Dimethylarginine) – Indicators of endothelial dysfunction and nitric oxide imbalance, both critical for vascular health.

Why it matters: Early changes in endothelial function and cardiac stress often appear years before symptoms, allowing for aggressive prevention.

3. Metabolic Panel

Metabolic health is the foundation of longevity. These labs measure inflammation, nutrient status, insulin sensitivity, and oxidative stress.

  • CBC with Differential – Basic measure of red and white blood cells, detecting anemia, infection, or immune stress.

  • Comprehensive Metabolic Panel (CMP) – Evaluates kidney, liver, and electrolyte function.

  • C-Reactive Protein (CRP) – A key marker of systemic inflammation.

  • Cystatin-C – Sensitive kidney function marker, superior to creatinine for early detection.

  • Hemoglobin A1c – Three-month average of blood sugar levels; higher levels indicate diabetes or prediabetes.

  • Insulin – Direct measure of insulin resistance, often abnormal years before blood sugar rises.

  • Adiponectin – A hormone that improves insulin sensitivity and reduces inflammation. Low levels suggest metabolic dysfunction.

  • Vitamin D – Essential for immune health, hormone regulation, and bone strength.

  • CoQ10 – A mitochondrial nutrient important for cellular energy and cardiovascular protection.

  • Vitamin B12 – Critical for energy production, nerve function, and DNA synthesis.

  • Homocysteine – Elevated levels increase cardiovascular and neurological risk.

  • Omega-3 Index – Assesses omega-3 fatty acid levels, important for reducing inflammation and supporting brain and heart health.

Why it matters: These labs detect metabolic syndrome, diabetes risk, nutrient deficiencies, and systemic inflammation—all key drivers of chronic disease.

4. Thyroid Panel

The thyroid regulates metabolism, energy, mood, and weight. Subtle thyroid dysfunction often goes undiagnosed, leading to fatigue, weight changes, and brain fog.

  • TSH (Thyroid Stimulating Hormone) – Primary screening test for thyroid disorders.

  • Free T4 – Active thyroid hormone circulating in the blood.

  • Free T3 – Most active thyroid hormone, essential for cellular energy.

  • Reverse T3 – Inactive form of thyroid hormone, often elevated in chronic stress or illness.

  • Anti-TG & Anti-TPO Antibodies – Autoimmune markers for Hashimoto’s thyroiditis.

Why it matters: Comprehensive thyroid testing catches issues like subclinical hypothyroidism, thyroid conversion problems, and autoimmune thyroid disease that basic TSH-only screening misses.

5. Male Hormone Panel

Hormone optimization is essential for energy, vitality, muscle strength, libido, and cardiovascular health in men.

  • Testosterone – Primary male sex hormone; low levels cause fatigue, low libido, and muscle loss.

  • Estradiol – Important for vascular and bone health; imbalance can lead to symptoms.

  • PSA (Prostate-Specific Antigen) – Screens for prostate inflammation and cancer risk.

Why it matters: This panel helps detect andropause, prostate disease, and hormonal imbalances that impact men’s healthspan.

6. Female Hormone Panel

Hormonal health is central to menstrual function, fertility, bone strength, metabolism, and cardiovascular health.

  • Testosterone – Plays a role in energy, libido, and muscle mass in women.

  • Estradiol – Major estrogen hormone; imbalances cause hot flashes, mood changes, and bone loss.

  • FSH (Follicle Stimulating Hormone) – Helps assess ovarian reserve and menopause transition.

  • Progesterone – Balances estrogen and supports reproductive and mood health.

Why it matters: Identifies perimenopause, menopause, estrogen dominance, and other hormonal imbalances affecting women’s long-term wellness.

Interpreting the Longevity Panel

Unlike routine labs that often flag only “disease states,” this panel provides a functional view of health:

  • High-sensitivity cardiovascular markers catch inflammation before a heart attack risk escalates.

  • Metabolic labs show insulin resistance years before diabetes develops.

  • Thyroid antibodies detect autoimmunity long before TSH is abnormal.

  • Hormone testing reveals imbalances that affect mood, energy, weight, and longevity.

This allows us to build a personalized, proactive plan for each patient.

Functional & Integrative Applications

Once results are in, our team designs a tailored plan that may include:

  • Nutrition optimization (anti-inflammatory, blood sugar–friendly eating).

  • Supplements: Vitamin D, Omega-3, CoQ10, B12, curcumin, Immuno-30, and more.

  • Peptide therapies: For metabolic health, hormone balance, and recovery.

  • Lifestyle interventions: Sleep, stress management, exercise, and detoxification strategies.

  • Hormone replacement therapy (when appropriate) to restore optimal levels.

Why the Longevity Panel Stands Out

  • Comprehensive: Covers heart, hormones, thyroid, metabolism, inflammation, and nutrition in one test.

  • Proactive: Detects problems before symptoms or disease develop.

  • Personalized: Results guide precision treatment tailored to each patient.

  • Prevention-focused: Supports long-term healthspan, not just disease care.

Conclusion

The Longevity Panel is more than a blood test—it’s a roadmap to optimal health. By measuring cardiovascular, metabolic, thyroid, and hormone markers in one comprehensive assessment, this panel uncovers the hidden risks and imbalances that shorten healthspan.

For patients at Revolution Health, the Longevity Panel is the foundation of our Core Health Assessment, giving us the tools to track progress, intervene early, and design personalized strategies for prevention, performance, and long-term vitality.