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June 30, 2025

Arterosil: Restore Your Endothelial Glycocalyx and Vascular Health

Learn how Arterosil protects and restores the endothelial glycocalyx, improving cardiovascular health, blood pressure, plaque, and microcirculation.

Arterosil: Restore Your Endothelial Glycocalyx and Vascular Health

Arterosil: The Endothelial Glycocalyx Supplement That’s Changing Cardiovascular Care

Cardiovascular disease remains the number one cause of death worldwide. For decades, cholesterol has been the centerpiece of prevention strategies, yet many people still suffer heart attacks, strokes, and vascular complications despite “normal” lipid levels. The problem? We’ve been focusing on the wrong layer of the artery.

A new wave of cardiovascular science points not at the cholesterol floating in your blood, but rather at the endothelial glycocalyx — a delicate gel-like lining that coats the inside of every blood vessel. Protecting and restoring this structure may be the key to halting atherosclerosis, reversing plaque, improving blood pressure, and optimizing circulation.

That’s where Arterosil® comes in.

What Is Arterosil?

Arterosil is a clinically studied, patented supplement that contains a unique sulfated polysaccharide complex derived from the green seaweed Monostroma nitidum. Its primary ingredient, rhamnan sulfate, has been shown to repair, protect, and regenerate the endothelial glycocalyx (EGX) — a vital but often overlooked barrier that lines every artery and capillary in the body.

Unlike cholesterol-lowering drugs, which target a symptom of vascular dysfunction, Arterosil works at the root: restoring the body’s natural defense against plaque formation, inflammation, and oxidative stress.

The Endothelial Glycocalyx: Your Arteries’ First Line of Defense

The endothelial glycocalyx (EGX) is a microscopically thin, sugar-rich layer that coats the inner surface of all blood vessels. It plays a pivotal role in vascular health:

  • Regulates vascular permeability (controls what gets in and out of the bloodstream)

  • Prevents plaque adhesion and clot formation

  • Serves as an antioxidant buffer, harboring enzymes like superoxide dismutase (SOD)

  • Senses shear stress from blood flow and triggers nitric oxide (NO) release

  • Modulates inflammation and immune cell interactions

When the EGX is healthy, arteries are flexible, blood pressure is regulated, and cholesterol is less likely to stick. But when the EGX is damaged, the door opens to:

  • Atherosclerosis

  • Hypertension

  • Heart attack and stroke

  • Diabetic complications

  • Erectile dysfunction

  • Neuropathy

  • Cognitive decline

What Damages the Endothelial Glycocalyx?

The glycocalyx is fragile and easily degraded by common modern insults:

These factors weaken the EGX, allowing cholesterol, white blood cells, and clotting factors to penetrate the endothelium, triggering plaque buildup and vascular disease.

How Arterosil Protects and Restores the Glycocalyx

Arterosil’s active ingredient, rhamnan sulfate, mimics the structure of native glycocalyx glycosaminoglycans and integrates into the damaged EGX to:

  • Rebuild the glycocalyx matrix

  • Prevent leukocyte (white blood cell) and platelet adhesion

  • Decrease vascular inflammation

  • Restore nitric oxide production

  • Reduce permeability and oxidative damage

  • Reverse early plaque formation

This isn’t theory — it’s been proven in multiple cellular, animal, and human studies, many of which were conducted under the guidance of world-renowned cardiovascular experts like Dr. Mark Houston.

Clinical Research on Arterosil: What the Science Says

1. Glycocalyx Regeneration Study (Cell Culture)

In a controlled study using human endothelial cells exposed to high glucose (which damages the glycocalyx), Arterosil restored the EGX in a dose-dependent manner. Fluorescent markers showed significant regeneration of the glycocalyx even after severe glucose-induced damage.

2. Leukocyte Adhesion Study (Animal Model)

In mice, removal of the EGX caused a spike in white blood cell adhesion — a key event in inflammation and plaque formation. However, mice treated with Arterosil after EGX removal showed rapid normalization of adhesion, demonstrating its anti-inflammatory vascular effects.

3. Arterial Elasticity Study (Human)

In a small human trial using FDA-approved pulse wave analysis (MaxPulse), patients taking Arterosil saw an 89.6% average improvement in arterial elasticity, a critical marker for cardiovascular risk.

4. Hypertension Study (Human)

Ten patients with uncontrolled high blood pressure were given Arterosil twice daily. After three months:

  • Diastolic blood pressure dropped significantly

  • Systolic blood pressure showed consistent improvement

  • No adverse effects were reported

This suggests that Arterosil may improve vascular tone by restoring nitric oxide bioavailability and EGX integrity.

5. Carotid Plaque Regression Study (MRI - Human)

Two subjects aged 65 with carotid artery plaque underwent 60 days of Arterosil therapy:

  • Lipid-rich necrotic core (LRNC) volume reduced by up to 64.3%

  • MRI imaging confirmed significant regression of vulnerable plaque

  • No other interventions were used during the study period

This finding suggests Arterosil’s potential as the first natural agent capable of regressing plaque by rebuilding the vessel wall’s defenses.

6. Diabetic Neuropathy Study (Human)

Twenty participants with Type 2 diabetes and peripheral neuropathy took Arterosil twice daily for three months:

  • NTSS-6 scores improved by 11%, indicating a reduction in numbness, burning, and pain

  • Microcirculation improved, as evidenced by increased nitric oxide and better C-fiber conduction

7. Rodent Atherosclerosis Study

In ApoE knockout mice predisposed to severe atherosclerosis:

  • Arterosil reduced plaque area by 60% and plaque volume by 39%

  • This study further validates its role in slowing and reversing plaque accumulation

Arterosil vs. Traditional Cardiovascular Supplements

Supplement Mechanism Targets Root Cause? Human Data? Patent Protected?
Arterosil EGX regeneration Yes Yes Yes
Fish Oil (Omega-3) Reduces inflammation Partial Yes No
CoQ10 Mitochondrial support Indirect Yes No
Garlic Cholesterol reduction Symptomatic Some No
Niacin Raises HDL Symptomatic Yes No

Arterosil stands out as a first-in-class supplement that doesn't just improve cardiovascular risk factors — it restores the vessel’s innate resilience.

Who Should Consider Taking Arterosil?

Arterosil is especially helpful for:

  • Men and women aged 45 and up as a vascular prevention tool

  • Anyone with atherosclerosis, plaque, or a family history of cardiovascular disease

  • Patients with diabetes or diabetic neuropathy

  • Individuals with hypertension, erectile dysfunction, or vascular dementia

  • People on hormone replacement therapy, as hormones rely on intact microcirculation

  • Athletes or high-performers looking to optimize vascular and nitric oxide function

Why Glycocalyx Health Matters for Hormone Optimization

Hormones such as testosterone, estrogen, and thyroid must pass through the vascular endothelium to reach target tissues. If the glycocalyx is damaged, hormones cannot effectively cross into cells.

For patients on bioidentical hormone replacement therapy (BHRT), Arterosil can:

  • Improve hormone delivery

  • Enhance tissue responsiveness

  • Reduce systemic inflammation

  • Improve sexual health and performance

How to Take Arterosil

Standard dosage:

  • 1 capsule twice daily with or without food

  • Each capsule contains 75mg of rhamnan sulfate extract

Clinical protocols often include:

  • 3-month minimum trial for arterial elasticity or plaque reversal

  • Combine with lifestyle changes and other vascular-supportive nutrients (e.g., Omega 1300, CoQ10 Omega, and Curcumin Complex)

Why Quality Matters: Physician-Supervised Only

Arterosil is not sold in retail stores and should never be purchased through unauthorized online retailers. It is only available:

  • Through licensed healthcare professionals

  • Available in our Clinic

  • Our online store: Arterosil

This ensures product purity, potency, and clinical relevance. You get what you pay for — and in cardiovascular health, that difference matters.

What Makes Arterosil Unique?

Patented for plaque stabilization and regression
Derived from clinically studied seaweed polysaccharides
Demonstrated in human MRI studies
Shown to improve endothelial function and arterial elasticity
Physician-exclusive for maximum efficacy and support

What Patients Are Saying

“My carotid plaque actually shrank on follow-up imaging after using Arterosil for three months. My cardiologist was stunned.” – Male, 68

“After starting Arterosil, my neuropathy symptoms began to fade and my blood pressure dropped into a healthy range.” – Female, 61

Final Thoughts: Repair the Barrier, Save the System

The future of cardiovascular care lies in preventing disease at the microscopic level. The glycocalyx is the gatekeeper of vascular health, and Arterosil is the only supplement clinically proven to regenerate it.

If you’re managing cardiovascular disease, preventing plaque, or looking to enhance hormone delivery and vascular performance, Arterosil deserves a central role in your strategy.

Call to Action

Interested in Arterosil?
Schedule a consultation with our clinic to determine whether Arterosil is right for your health goals. Our providers will review your cardiovascular history, order any necessary labs or imaging, and create a personalized vascular health plan.

Online Store?
Visit our online store and purchase direct.

Scientific References

  • van den Berg BM, Vink H, Spaan JAE. Circulation Research (2003); 92:592–594

  • Becker BF, Chappell D, Jacob M. Basic Res Cardiol. 2010;105(6):687-701

  • Cancel LM, Tarbell JM. The FASEB Journal. 2013;27(S1):896.3

  • Houston M, et al. Human clinical trials, 2021–2023

  • Okamoto T, et al. J Nat Med. 2019;73(3):614–619

  • Raposo MF, et al. Mar Drugs. 2013;11(1):233–252