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Prolotherapy is a regenerative injection treatment that stimulates your body’s natural healing response to repair ligaments, tendons, and joints. By strengthening connective tissue and improving stability, it reduces pain and helps you return to the activities you love.
Platelet-Rich Plasma (PRP) therapy concentrates platelets from your own blood to deliver potent growth factors that accelerate tissue repair and calm inflammation. As a stronger step beyond prolotherapy, PRP helps heal stubborn tendon, ligament, and joint injuries without surgery.
BMAC stem cell therapy uses your own bone marrow aspirate concentrate to deliver stem cells and bioactive growth factors directly to damaged joints. This advanced regenerative option supports cartilage repair, reduces inflammation, and helps restore mobility in more severe hip, knee, or shoulder conditions.
Prolotherapy, short for “proliferant therapy,” is the foundation of regenerative injection treatments. It works by injecting a natural solution—most often dextrose—into injured ligaments, tendons, or joints. This triggers a mild, localized inflammatory response that stimulates your body’s innate healing mechanisms. Over time, this process strengthens weakened tissues, stabilizes joints, and reduces chronic pain. Unlike medications that simply mask symptoms, prolotherapy addresses the root cause of instability and degeneration.
Benefits of Prolotherapy
Ideal Candidates for Prolotherapy
Prolotherapy is well-suited for patients with:
Description
Platelet-Rich Plasma (PRP) therapy takes the concept of prolotherapy a step further by using your body’s own healing cells and growth factors. A small sample of your blood is drawn, spun in a centrifuge, and concentrated to isolate platelets. These platelets are rich in growth factors that accelerate tissue repair, reduce inflammation, and enhance regeneration. When injected into injured areas, PRP delivers a more potent healing signal than prolotherapy alone.
Potency vs. Prolotherapy
Use Cases for PRP
PRP therapy is an excellent option for patients with:
Stem cell therapy is the most advanced option in regenerative medicine, designed for patients with more significant joint or cartilage problems. At Revolution Health, we use BMAC (Bone Marrow Aspirate Concentrate) autologous stem cells, which are harvested directly from your own bone marrow. These cells are rich in stem cells and growth factors that signal repair, regenerate damaged tissue, and reduce inflammation. When injected into injured joints, stem cells offer powerful potential for long-term healing and restoration.
Stem cell therapy is ideal for patients with:
| Therapy | How It Works | Best For | Potency | Typical Course | Cost | Pros | Considerations |
|---|---|---|---|---|---|---|---|
| Prolotherapy | Injected proliferant (often dextrose) triggers a mild, localized inflammatory response to activate the body’s innate healing and strengthen connective tissues. | Ligament/tendon laxity, chronic sprains/strains, mild–moderate joint instability, early osteoarthritis. | Good | Series of sessions spaced 3–6 weeks apart; number varies by condition and response. | $$ (most cost-effective) | Non-surgical, low downtime, addresses root-cause instability, broad applicability. | Requires multiple sessions; gradual improvement; not ideal for advanced cartilage loss. |
| PRP (Platelet-Rich Plasma) | Concentrated platelets deliver growth factors that accelerate tissue repair, modulate inflammation, and enhance regeneration at the injury site. | Partial tendon/ligament tears, persistent tendinopathy, early–moderate osteoarthritis, sports injuries, post-procedure healing. | Better (higher biologic signal than prolotherapy) | Often 1–3 sessions spaced 4–8 weeks apart; may combine with rehab protocols. | $$$ | Uses your own blood; stronger effect than prolotherapy; helpful when prior care plateaued. | Higher cost; transient soreness/swelling; results vary with severity and site. |
| Stem Cell (BMAC) | Autologous bone marrow aspirate concentrate (BMAC) provides stem cells and bioactive signals that support tissue regeneration and anti-inflammatory effects. | Advanced hip/knee/shoulder osteoarthritis, significant cartilage loss, large or chronic joint injuries, cases aiming to delay joint replacement. | Best (most robust regenerative option) | Typically single session with structured follow-up; may pair with targeted rehab. | $$$$ (highest investment) | Strongest biologic signal; suitable for advanced pathology; potential to reduce surgery need. | Highest cost; not first-line for mild cases; eligibility depends on clinical evaluation. |
Research, and our experience, shows that the injections result in sustained, long-term benefits lasting in excess of 14 years.
Receiving injections into an area which is already tender is often uncomfortable. However, it is generally well tolerated and the discomfort only lasts seconds to minutes.
Prolotherapy is generally 3-6 treatments
PRP is generally 2-4 treatments
Stem Cell is generally a single treatment
We harvest your own stem cells from your bone marrow (iliac crest). Don't let that scare you. We use sufficient amounts of local anesthetic and the procedure is very well tolerated.
This is different for each patient, the injury, the location, and your budget. We'll discuss the options and help you reach the decision that works best for you.
Schedule your consultation today and explore whether prolotherapy, PRP, or Stem Cell therapy is right for you.
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