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May 11, 2025

Peptide Therapy - CJC-1295

Explore how CJC-1295 improves growth hormone levels, supports recovery, and promotes anti-aging. See why CJC-1295 without DAC may deliver better results.

CJC without DAC peptide

CJC-1295 Peptide Therapy: The Growth Hormone Secretagogue That Mimics Nature

If you’re exploring peptide therapy for recovery, anti-aging, or body composition goals, chances are you’ve heard of CJC-1295 — one of the most clinically relevant and widely used growth hormone–releasing hormones (GHRHs) available today. But not all versions of CJC-1295 are created equal.

In this comprehensive guide, we’ll dive deep into:

  • What CJC-1295 is and how it works

  • The difference between CJC-1295 with DAC and without DAC

  • Why we recommend CJC-1295 without DAC at our clinic

  • How to properly reconstitute and dose the peptide

  • Benefits for fat loss, muscle growth, sleep, recovery, and more

  • Clinical use cases, safety, and what the research says

What Is CJC-1295?

CJC-1295 is a synthetic growth hormone–releasing hormone analog (GHRH analog). Its primary job is to stimulate the pituitary gland to release more growth hormone (GH) — which in turn increases IGF-1, a powerful anabolic and regenerative hormone.

Unlike taking exogenous human growth hormone (HGH) — which suppresses your natural production and carries long-term risks — CJC-1295 works with your body to enhance its own GH release, preserving the natural rhythm and feedback loops of the endocrine system.

Why Growth Hormone Matters

Growth hormone plays a central role in:

  • Fat metabolism (especially visceral fat loss)

  • Muscle maintenance and repair

  • Deep sleep (Stage 3)

  • Bone density

  • Skin elasticity and collagen production

  • Recovery from injury and workouts

  • Cognitive health and neuroprotection

  • Insulin sensitivity and metabolic health

Unfortunately, GH levels naturally decline with age — often dropping by 50% or more between ages 30 and 60. That’s where peptides like CJC-1295 come in.

CJC-1295 with DAC vs. without DAC: What’s the Difference?

There are two distinct versions of CJC-1295 on the market:

Feature CJC-1295 with DAC CJC-1295 without DAC
DAC = Drug Affinity Complex Present – extends half-life Absent – shorter, physiologic duration
Half-Life ~8 days ~30 minutes
GH Pulse Pattern Less physiologic (long, sustained exposure) Mimics natural GH pulses (short, sharp)
Dosing Frequency 1–2x per week 5x per week
Research More published studies Less formal research, but growing
Clinical Preference Bulk GH increase Balanced, rhythmic GH signaling
Our Recommendation Not preferred Yes — better physiologic mimicry

We recommend CJC-1295 without DAC because it better mirrors the body’s natural pulsatile release of GH, avoids desensitization, and likely supports more favorable long-term outcomes for body composition, performance, and longevity.

How CJC-1295 (Without DAC) Works

CJC-1295 binds to GHRH receptors in the anterior pituitary, stimulating a brief but potent release of growth hormone. When paired with a GH-releasing peptide (GHRP) such as Ipamorelin, the signal is amplified through a dual-pathway mechanism.

This burst of GH:

  • Triggers fat breakdown (lipolysis)

  • Stimulates IGF-1 production by the liver

  • Enhances protein synthesis and tissue repair

  • Promotes better sleep and cognitive clarity

Because it’s pulsed — not constant — the body avoids receptor downregulation and maintains feedback sensitivity.

CJC-1295 Without DAC: Protocol and Dosing Instructions

Our clinic offers CJC-1295 without DAC in 10mg vials. Here’s how to properly reconstitute and use it.

Reconstitution:

  • Add 2mL of sterile or bacteriostatic water to the 10mg vial

  • This results in a concentration of 0.5mg (10 units) per 0.2mL

Dosing Options:

Protocol 1 (Standard):

  • Inject 0.5mg (10 units) SubQ

  • 5 days per week, take 2 days off

  • Best taken at night or in a fasted state

Protocol 2 (Aggressive):

  • Inject 1mg (20 units) SubQ

  • 5 days per week, take 2 days off

  • For advanced goals such as body recomposition or recovery

Cycle Duration:

  • Continue for up to 90 consecutive days

  • Take at least 1 month off before starting another cycle

This cycling supports hormonal sensitivity and long-term efficacy.

Expected Benefits of CJC-1295 Without DAC

Patients using CJC-1295 without DAC commonly report:

1. Fat Loss (Especially Belly Fat)

  • Increases basal metabolic rate

  • Enhances lipolysis in visceral and subcutaneous fat

2. Muscle Preservation and Growth

  • Stimulates IGF-1 and protein synthesis

  • Helps retain lean mass during weight loss or fasting

3. Faster Recovery

  • Speeds repair of tissues, tendons, and ligaments

  • Useful for injury rehabilitation or heavy training blocks

4. Improved Sleep Quality

  • Enhances Stage 3 deep sleep, when GH is naturally secreted

  • Promotes mental clarity and energy

5. Better Skin, Hair, and Nails

  • Supports collagen production

  • Slows visible signs of aging

6. Brain and Mood Benefits

  • Improves neurogenesis and brain-derived growth factors

  • Often reported to enhance mood, memory, and cognitive sharpness

Pairing CJC-1295 with Other Peptides

For enhanced results, CJC-1295 is often combined with synergistic peptides:

Peptide Purpose Dosing Notes
Ipamorelin GHRP that amplifies GH release Combine with CJC for dual-pulse signal
Tesamorelin FDA-approved for visceral fat loss Use separately or alternate with CJC
BPC-157 + TB-500 Tissue repair and inflammation support For injury or chronic pain
Follistatin Muscle-building and fat-loss synergy Cycled in 4–6 week blocks

Scientific Research Supporting CJC-1295

While more studies have been conducted on CJC-1295 with DAC, early research and clinical observation of non-DAC CJC-1295 suggest equivalent or superior outcomes when considering physiologic mimicry.

Key study findings on CJC-1295 (mostly with DAC):

  • Increased IGF-1 by 2–3x baseline levels

  • Sustained GH secretion for up to a week (DAC version)

  • Improved protein synthesis and nitrogen balance

  • Positive effects on body composition and recovery

However, non-DAC CJC-1295 better mimics the body’s natural ultradian rhythm of GH secretion, making it the ideal choice for functional, anti-aging, and metabolic protocols.

Side Effects and Safety Profile

CJC-1295 without DAC is generally well tolerated, especially when physician-supervised. Some potential side effects may include:

  • Mild injection site irritation

  • Temporary water retention (rare)

  • Increased hunger (via IGF-1 signaling)

  • Vivid dreams (due to improved deep sleep)

  • Fatigue or lethargy if overdosed

Caution: Do not use in individuals with active or suspected cancer, as GH and IGF-1 can stimulate cell growth. Always consult a licensed provider before use.

Why We Choose CJC-1295 Without DAC

We have seen better clinical outcomes using CJC-1295 without DAC compared to the DAC version. Our reasons:

  • More natural GH rhythm

  • Less receptor desensitization

  • Better synergy with other peptides

  • Fewer sustained elevation side effects

It simply aligns better with the body’s natural signaling systems — and in functional medicine, mimicking physiology always wins.

Who Should Consider CJC-1295 Peptide Therapy?

CJC-1295 without DAC is ideal for:

  • Adults 35+ seeking GH restoration

  • Those pursuing fat loss, especially belly fat

  • Athletes and weekend warriors recovering from injury

  • Biohackers interested in longevity and optimization

  • Individuals with poor sleep, fatigue, or slow recovery

  • Anyone needing improved body composition and performance

How to Get Started with CJC-1295

Step 1: Schedule a Peptide Evaluation

We offer brief telehealth consultations to determine if CJC-1295 is right for your goals.

Step 2: Complete Your Medical Intake

We’ll review your symptoms, labs, goals, and history of hormone or peptide use.

Step 3: Receive Your Vial

Your 10mg vial will be shipped from an FDA-regulated facility with dosing instructions.

Step 4: Start Your Protocol

Choose between 0.5mg or 1mg SubQ 5x/week, and track progress over 90 days.

Final Thoughts: The Smarter Way to Boost Growth Hormone

CJC-1295 without DAC gives you all the benefits of growth hormone therapy — without suppressing your natural production or inviting long-term risks. When used under medical supervision, it’s one of the safest, most effective ways to improve metabolism, energy, recovery, and aging.

If you’re serious about performance, health span, or healing — CJC-1295 deserves a spot in your protocol.

Call to Action

Ready to optimize your recovery, sleep, and fat loss with CJC-1295?

Schedule your New Patient Peptide Evaluation today and let our team create your personalized plan. All peptides are sourced from FDA-monitored facilities and available only through physician-supervised protocols.

Already a patient? Contact us through the portal to order your CJC-1295 without DAC and begin your next cycle.

Scientific References

  1. Teichman SL, Neale AR, Lawrence B, Gagnon C, et al. "Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone." J Clin Endocrinol Metab. 2006;91(2):799-805.

  2. Walker RF, et al. "Growth hormone releasing peptides: status and therapeutic potential." Drugs. 1994;48(3):513-533.

  3. Veldhuis JD, et al. "Pulsatile secretion of growth hormone (GH): regulation, patterns, and implications." Endocr Rev. 1991;12(2):210-240.