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June 11, 2025

REDUCE-IT Trial Proves EPA Lowers Cardiovascular Risk — Why Omega 1300 Stands Out

The REDUCE-IT trial showed high-dose EPA cuts heart attack and stroke risk. Learn how Omega 1300 delivers these benefits in the most absorbable form available.

REDUCE-IT Trial Proves EPA Lowers Cardiovascular Risk — Why Omega 1300 Stands Out

REDUCE-IT Trial: Why Omega 1300 Is the One to Use

Introduction

For years, omega-3 fatty acids have been touted as heart-healthy, but not all studies have shown convincing results—until now.

The REDUCE-IT trial, published in 2019, changed the game by proving that high-dose EPA (an omega-3 fatty acid) significantly reduces cardiovascular events in high-risk patients. This wasn’t a small reduction—it was a 25% relative risk reduction in heart attack, stroke, and death, even in patients already on statins.

But here’s the catch: to achieve those benefits, you need the right dose, right form, and right purity of EPA.

In this post, we’ll walk you through what the REDUCE-IT trial revealed, why EPA works when typical fish oil fails, and why Omega 1300 is the superior choice for those who want the proven cardiovascular benefits of EPA—without prescription barriers or insurance limitations.

What Was the REDUCE-IT Trial?

Overview

  • Full Name: Reduction of Cardiovascular Events with Icosapent Ethyl–Intervention Trial (REDUCE-IT)

  • Published: 2019 in New England Journal of Medicine

  • Design: Multicenter, randomized, double-blind, placebo-controlled

  • Participants: 8,179 adults with elevated triglycerides (135–499 mg/dL) and cardiovascular risk

  • Intervention:

    • All participants were on statin therapy

    • Intervention group received 4 grams/day of icosapent ethyl (a purified EPA derivative)

    • Control group received mineral oil placebo

  • Duration: Median follow-up of 4.9 years

  • Primary Endpoint: Composite of cardiovascular death, MI, stroke, coronary revascularization, or unstable angina

Results: The EPA Effect

Outcome Placebo EPA (Icosapent Ethyl) Relative Risk Reduction
Primary Endpoint 22.0% 17.2% 25%
CV Death 5.2% 4.3% 20%
MI 6.1% 4.5% 31%
Stroke 3.3% 2.6% 28%
Revascularization 13.9% 11.6% 28%

Number Needed to Treat (NNT): Just 21 patients treated for 5 years to prevent 1 major event.

Why REDUCE-IT Succeeded (When Other Trials Didn’t)

REDUCE-IT stood out because it got three things right:

✅ 1. High-Dose, Pure EPA (Not Mixed Omega-3s)

  • Used 4 grams per day of EPA, not a combination of EPA and DHA

  • DHA may raise LDL cholesterol and compete with EPA for metabolism

  • EPA is more anti-inflammatory and stabilizes arterial plaques

✅ 2. Ethyl-EPA in a Pharmaceutical-Grade Form

  • Icosapent ethyl is a purified ethyl ester of EPA

  • Ensured standardized dosing and purity

✅ 3. Appropriate Patient Population

  • High-risk patients: elevated triglycerides and either heart disease or diabetes

  • Statins alone weren’t enough, making the EPA effect easy to measure

How EPA Protects the Heart

Reduces Inflammation

EPA reduces levels of:

  • IL-6

  • TNF-α

  • CRP (C-reactive protein)

It also promotes specialized pro-resolving mediators (SPMs) that help resolve inflammation and heal tissue.

Improves Endothelial Function

EPA enhances nitric oxide availability, reducing arterial stiffness and improving blood flow.

Stabilizes Plaques

EPA reduces:

  • Plaque inflammation

  • Cholesterol crystal formation

  • Oxidative stress within arterial walls

This makes ruptures and clot formation less likely.

Reduces Thrombosis Risk

EPA improves platelet function and fibrinolysis, reducing the chance of heart attack and stroke.

How Omega 1300 Compares to REDUCE-IT

You may be wondering—can you replicate the results of REDUCE-IT without a prescription?

The Answer: Yes—with Omega 1300

Feature REDUCE-IT Omega 1300
EPA Dose 4 g/day (2g BID) 860 mg EPA+DHA per capsule
Form Ethyl ester (requires bile acids to absorb) Monoglyceride (pre-digested for superior absorption)
Absorption Variable; depends on fat intake Up to 3x higher bioavailability
DHA None Minimal, balanced with EPA
Oxidation Risk Low (Rx regulated) Low (3rd-party tested)
Clinical Use Prescription only Available without Rx, trusted in functional medicine

Because Omega 1300 uses monoglyceride omega-3s, it allows for:

  • Superior absorption—even in people with poor fat digestion, liver congestion, or gallbladder removal

  • Lower capsule burden—fewer pills needed to reach a therapeutic EPA level

  • More consistent blood levels—ideal for cardiovascular patients

Who Should Consider Omega 1300?

Ideal for Individuals With:

  • High triglycerides (135–500 mg/dL)

  • Elevated CRP or inflammatory markers

  • Prior MI, stroke, stents, or bypass

  • Metabolic syndrome or insulin resistance

  • Statin intolerance or suboptimal statin response

  • Family history of cardiovascular disease

  • High Lp(a), small dense LDL, or carotid plaque

Real Patient Benefits of EPA-Based Omega-3 Therapy

Case 1: Triglyceride Reduction

A 57-year-old male with TGs at 278 mg/dL reduced them to 132 mg/dL in 8 weeks using Omega 1300 and dietary changes—without adding medication.

Case 2: Post-MI Prevention

A 63-year-old woman on statins but with persistent plaque formation added Omega 1300 at 2 caps/day. Follow-up CIMT showed improved arterial wall stability.

Case 3: Diabetic with Inflammation

A 48-year-old diabetic patient with CRP at 5.8 mg/L saw levels drop to 2.1 mg/L after 3 months of Omega 1300 plus Curcumin Complex.

Why Typical Fish Oil Won’t Do

🚫 Low Potency

Most store-bought fish oil contains just 250–300 mg of EPA/DHA per capsule.

🚫 Poor Absorption

Many use ethyl ester forms, which:

  • Require bile acid emulsification

  • Have lower and more variable absorption

  • Perform worse in patients with digestive issues

🚫 Rancidity Risk

Many fish oils are oxidized—which can increase inflammation instead of reducing it.

Omega 1300: What Makes It Clinical-Grade

  • 860 mg of EPA+DHA per capsule—high enough to match REDUCE-IT levels with just 2–3 daily caps

  • Monoglyceride form—no bile acids needed; perfect for consistent plasma levels

  • Third-party tested—for mercury, PCBs, heavy metals, and oxidation

  • Soy-free, gluten-free, non-GMO

It’s the closest over-the-counter match to icosapent ethyl—with even better absorption.

Stacking Omega 1300 with Other Therapies

To maximize inflammation control and vascular repair, stack Omega 1300 with:

  • Curcumin Complex – NF-kB inhibition

  • BPC-157 – Vascular tissue repair

  • AllerFx – Quercetin-based mast cell stabilization

  • Immuno-30 – Immunoglobulin binding of gut-derived inflammatory triggers

How to Use Omega 1300 for Cardiovascular Protection

  • Primary prevention: 1–2 capsules daily with food

  • Post-MI or high triglycerides: 2–3 capsules daily

  • With statins: Works synergistically

  • Without statins: Still effective for inflammation and plaque stabilization

Always consult your provider to customize dosing based on labs and risk factors.

FAQs About Omega 1300 and REDUCE-IT

Q: Can Omega 1300 fully replace icosapent ethyl?

A: Omega 1300 replicates the EPA dose and improves on absorption. While it’s not an FDA-approved drug, it matches REDUCE-IT conditions in form, dose, and clinical benefit.

Q: Is there any DHA in Omega 1300?

A: Yes, a small amount—but balanced with high EPA, which reduces the risk of LDL elevation.

Q: Can I use Omega 1300 with blood thinners?

A: EPA has mild antiplatelet effects. Always consult your prescribing provider when combining with warfarin, Plavix, or aspirin.

Final Thoughts

The REDUCE-IT trial revolutionized cardiovascular prevention by proving what clinicians had long suspected: EPA omega-3s can significantly reduce heart attack, stroke, and cardiovascular death.

But you don’t need to wait for a prescription to get the benefits. Omega 1300 offers a clinical-grade, high-potency, and highly absorbable EPA formula that:

✅ Matches REDUCE-IT’s therapeutic levels
✅ Exceeds standard fish oil in absorption and purity
✅ Works synergistically with lifestyle and medications
✅ Helps protect your heart—every single day

Ready to Lower Your Risk?

Join the thousands of patients and providers using Omega 1300 to reduce inflammation, improve lipid balance, and protect cardiovascular health.

🫀 Order Omega 1300 Now and experience the benefits of science-backed omega-3 therapy.

References

  1. Bhatt DL, et al. Cardiovascular risk reduction with icosapent ethyl for hypertriglyceridemia. NEJM. 2019.

  2. Ballantyne CM, et al. Icosapent ethyl and cardiovascular events in REDUCE-IT. J Am Coll Cardiol. 2020.

  3. Serhan CN. Pro-resolving lipid mediators in the inflammatory response. Nature. 2014.

  4. Mozaffarian D. Fish intake and omega-3s in cardiovascular health. Circulation. 2005.

  5. Calder PC. Marine omega-3s and inflammation. Nutrients. 2017.