The Ultimate Weight Loss Peptide Blend: SLU-PP-332, 5-Amino-1MQ, and BPC-157

Peptides are transforming the way we approach fat loss, metabolic health, and healing. At the forefront of this transformation is a powerful new combination therapy known as the Weight Loss Blend, featuring three synergistic peptides:

• SLU-PP-332 – a PPARδ agonist for metabolic enhancement

• 5-Amino-1MQ – a fat loss catalyst targeting methylation and energy balance

• BPC-157 – a regenerative peptide known for gut, vascular, and tissue healing

Together, they offer a multidimensional strategy for sustainable fat loss, improved energy, reduced inflammation, and accelerated tissue repair.

This article will break down:

• How each peptide works

• The synergy of this blend

• Clinical applications

• How to use this blend as part of a comprehensive fat loss protocol

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Why Traditional Weight Loss Strategies Often Fail

Before diving into peptides, it’s important to understand why conventional fat loss approaches are often ineffective long-term:

• Calorie restriction alone slows metabolism

• Yo-yo dieting increases fat regain

• Chronic inflammation and insulin resistance block fat burning

• Loss of muscle mass reduces metabolic rate

• Environmental toxins and stress impair mitochondrial function

The Weight Loss Blend addresses these problems by reprogramming metabolic function, enhancing mitochondrial energy, improving insulin sensitivity, and supporting muscle retention—all while reducing inflammation.

Why an Oral Format Matters

Unlike other peptide blends requiring injection, this is an oral tablet. That offers several advantages:

• Greater accessibility and ease of use

• Improved compliance and user convenience

• Lower barrier for initial adoption in research or clinical protocols

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SLU-PP-332: The Metabolic Ignition Switch

SLU-PP-332 is a novel PPARδ (peroxisome proliferator-activated receptor delta) agonist. PPARδ is a nuclear receptor involved in fat oxidation, energy expenditure, and mitochondrial function.

Key Benefits:

• Enhances fatty acid oxidation

• Increases skeletal muscle mitochondrial biogenesis

• Improves endurance capacity

• Reduces fat mass while preserving lean mass

• Decreases systemic inflammation

In animal studies, SLU-PP-332 activated PPARδ similarly to exercise—without requiring exercise itself. Subjects showed enhanced energy metabolism, reduced body fat, and improved insulin sensitivity.

This makes SLU-PP-332 an ideal peptide for:

• Individuals with metabolic syndrome

• Those unable to exercise intensely

• Patients experiencing weight-loss resistance

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5-Amino-1MQ: Methylation, NAD+, and Fat Loss

5-Amino-1MQ targets the enzyme NNMT (nicotinamide N-methyltransferase), which plays a role in energy regulation and fat storage.

What Happens When NNMT Is Inhibited?

• NAD+ levels rise (a key molecule in energy production)

• Mitochondrial efficiency improves

• Fatty acid oxidation increases

• Adipogenesis (fat cell development) decreases

In animal studies, 5-Amino-1MQ:

• Reduced body fat by 30–40%

• Increased lean muscle mass

• Improved insulin sensitivity and glucose regulation

Additionally, it helps preserve metabolic rate during calorie restriction—a major factor in long-term fat loss success.

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BPC-157: The Regenerative Anchor

BPC-157 (Body Protection Compound 157) is a peptide originally isolated from gastric juice and widely studied for its healing properties.

While it’s not traditionally viewed as a fat-loss peptide, it plays a crucial supporting role in the blend:

BPC-157 Benefits:

• Repairs gut lining (essential for metabolism and inflammation control)

• Accelerates tendon, ligament, and muscle recovery

• Enhances nitric oxide signaling (improves circulation and fat mobilization)

• Reduces systemic and local inflammation

• Supports insulin sensitivity through gut barrier restoration

Chronic inflammation and leaky gut are major roadblocks in metabolic health. By healing tissue and reducing inflammation, BPC-157 allows SLU-PP-332 and 5-Amino-1MQ to work more effectively.

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How These Peptides Work Together

Peptide	Primary Mechanism	Main Benefits
SLU-PP-332	PPARδ activation	Boosts fat oxidation, muscle energy, endurance
5-Amino-1MQ	NNMT inhibition	Enhances NAD+, promotes fat loss, improves insulin
BPC-157	Gut and vascular repair	Supports healing, reduces inflammation, enhances peptide uptake

Synergy in Action:

• SLU-PP-332 turns on fat burning.

• 5-Amino-1MQ enhances mitochondrial energy and NAD+ to drive metabolism.

• BPC-157 heals the gut and supports hormonal and metabolic signaling.

This trifecta addresses the most common barriers to fat loss:  activating fat burning (SLU-PP-332), enhancing energy (5-Amino-1MQ), and accelerating repair (BPC-157).

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Clinical Applications: Who Is This For?

The Weight Loss Blend is ideal for patients who struggle with:

• Stubborn visceral fat

• Insulin resistance or metabolic syndrome

• Fatigue and poor mitochondrial function

• Gut permeability and chronic inflammation

• Post-injury weight gain or loss of muscle mass

• Perimenopausal or age-related fat accumulation

It's especially helpful for:

• Midlife men and women with hormone imbalances

• Athletes recovering from injury

• Patients who have failed on GLP-1 medications alone

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How to Use This Blend: Suggested Protocol

Note: this is educational only. Administer only under medical supervision.

Suggested Dosing:

• Standard Protocol: Take 1 tablet daily, ideally in the morning on an empty stomach to optimize NAD+ support and fat oxidation.

• High-Dose Protocol: Some individuals may benefit from 1 tablet twice daily, particularly if they are dealing with significant metabolic resistance, inflammation, or advanced body composition goals. This higher-dose option should always be supervised by a qualified provider.

• Each bottle contains 90 tablets, offering up to a 3-month supply at standard dosing or 6 weeks at high-dose.

Dosing Duration:

• Use continuously for 4–12 weeks

• Follow with a 2–4 week break or reassessment period

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Stacking with other fat loss peptides (e.g., CJC-1295/Ipamorelin, Tesamorelin, MOTS-c) can yield further metabolic enhancement if appropriate.

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Supportive Supplements to Maximize Results

To optimize the impact of the Weight Loss Blend, incorporate functional supplements that enhance detox, fat oxidation, and insulin sensitivity.

Recommended:

• Omega-3 fatty acids → Omega 1300

• Berberine or Metformin (if prescribed)

• NAD+ precursors → NMN or NR for energy support

• Sulforaphane → Detox 2.0

• Probiotic and gut repair support → ProbioHealth 350, Immuno-30

• Magnesium, B vitamins, and trace minerals to support mitochondrial enzymes

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Nutrition and Lifestyle Recommendations

Even the best peptide won’t work in a vacuum. Here’s how to maximize your results:

Nutrition

• Follow a high-protein, low-glycemic, anti-inflammatory diet

• Eliminate processed foods and seed oils

• Consider intermittent fasting (16:8 or 18:6)

Exercise

• Prioritize Zone 2 cardio for fat oxidation

• Incorporate resistance training 3–4x/week to preserve muscle

• Walk after meals to reduce blood sugar spikes

Sleep and Stress

• Aim for 7–8 hours of high-quality sleep

• Use mindfulness practices or adaptogens to regulate cortisol

• Avoid overtraining or excessive stimulant use

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Frequently Asked Questions

Can I use it with other peptides or medications?
Yes. It pairs well with MOTS-c, CJC-1295/Ipamorelin, GLP-1s, tesamorelin, and AOD-9604 when monitored properly.

Will I lose muscle?
Unlikely. This blend helps preserve lean mass through enhanced mitochondrial activity and energy efficiency.

Is cycling required?
We recommend using the blend for 4–12 weeks, followed by a brief washout (2–4 weeks). Your provider may personalize your cycle length.

Is this blend safe for women?
Yes. It’s effective for both men and women, especially those with perimenopausal or estrogen-dominant fat patterns.

Can this replace GLP-1 medications?
For some, yes—especially those who cannot tolerate semaglutide or tirzepatide. For others, it may complement GLP-1 therapy.

Will I lose muscle with this blend?
No. In fact, SLU-PP-332 and 5-Amino-1MQ both preserve or build lean mass. This is a major advantage over traditional weight loss drugs.

Do I need labs before using this blend?
It’s recommended. Key markers include:

• Fasting glucose and insulin

• hs-CRP and liver function

• Estradiol, testosterone, DHEA

• DEXA scan for body composition baseline

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Summary: Why the Weight Loss Blend Works

Peptide therapies are at the frontier of precision weight loss and metabolic optimization. By combining three powerful agents—SLU-PP-332, 5-Amino-1MQ, and BPC-157—this Weight Loss Blend addresses fat loss from every angle:

✅ Turns on fat-burning genes
✅ Enhances energy and mitochondrial output
✅ Repairs tissue and reduces inflammation
✅ Improves insulin sensitivity
✅ Supports long-term metabolic health

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Ready to Try the Weight Loss Blend?

If you’re tired of yo-yo dieting, fatigued by one-size-fits-all prescriptions, and ready to optimize your fat-burning physiology at the cellular level—the Weight Loss Blend may be exactly what your metabolism needs.

Contact our team at Revolution Health & Wellness to explore if this blend is right for your goals. Our physician-supervised protocols ensure safety, efficacy, and tailored results.

💉 Available to current patients only. Peptides are for research use and not FDA-approved for weight loss.

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References

1. Narkar, V. A., et al. (2008). AMPK and PPARδ agonists mimic exercise to increase endurance. Cell, 134(3), 405–415.

2. Kraus, D., et al. (2014). NNMT: linking obesity to insulin resistance and inflammation. Nature Metabolism.

3. Olszanecki, R., et al. (2003). BPC-157 accelerates healing and modulates NO system. Journal of Physiology and Pharmacology.

4. Lee, J., et al. (2021). 5-Amino-1MQ as a potential obesity treatment via NAD+ modulation. Frontiers in Pharmacology.

5. Geiger, J., et al. (2022). Peptides in metabolic syndrome: emerging therapeutics. Trends in Endocrinology & Metabolism.

6. Marton, J., et al. (2015). Gut permeability, inflammation, and metabolic disease. World Journal of Gastroenterology.

7. Yasmeen, R., et al. (2010). Role of PPARδ in fatty acid metabolism and exercise capacity. Biochemical Journal.

8. Chrousos, G. P. (2000). Stress and disorders of the stress system. Nature Reviews Endocrinology.