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June 07, 2025

EstroProtect for Estrogen Detox & Hormone Balance

EstroProtect supports all three phases of estrogen detox with DIM, calcium D-glucarate, sulforaphane, and active B vitamins. Ideal for hormone balance.

EstroProtect for Estrogen Detox & Hormone Balance

EstroProtect: A Functional Medicine Approach to Estrogen Metabolism Support

Hormone imbalance is one of the most common, yet under-recognized, root causes of fatigue, mood changes, stubborn weight, and cycle-related symptoms in both women and men. If you’ve struggled with estrogen dominance symptoms—like bloating, breast tenderness, irregular periods, or even fibroids—EstroProtect offers a thoughtful, targeted solution grounded in functional medicine.

This supplement is more than just a DIM formula. It supports all three phases of estrogen detoxification with key nutrients that promote healthy metabolism, detox, and elimination—essential for hormonal balance, especially in estrogen-sensitive individuals.

What Is EstroProtect?

EstroProtect is a nutraceutical designed to support the breakdown and elimination of estrogen in a way that minimizes harmful metabolites and promotes protective ones. It helps your body shift from potentially risky estrogen pathways to safer, less proliferative ones. The goal is not to lower estrogen arbitrarily, but to improve how your body processes and clears it.

This is especially helpful if you’re dealing with:

  • Premenstrual syndrome (PMS)

  • Heavy or irregular cycles

  • Endometriosis or fibroids

  • Perimenopausal symptoms

  • PCOS with estrogen imbalance

  • Estrogen-sensitive cancers (under medical guidance)

  • Poor methylation or COMT gene variants

Why Estrogen Metabolism Matters

Your body processes estrogen through a series of biochemical reactions in the liver and gut, generally broken into three key phases:

1. Phase I – Hydroxylation

In the liver, estrogen is transformed into one of several metabolites:

  • 2-OH estrogen (protective)

  • 4-OH estrogen (potentially carcinogenic)

  • 16α-OH estrogen (highly estrogenic and inflammatory)

The goal is to favor 2-OH production and minimize 4-OH and 16-OH pathways.

2. Phase II – Conjugation (Methylation, Glucuronidation, Sulfation)

These modified estrogens are further processed so they can be excreted safely. This requires methyl donors (like folate, B12, and B6), glucarate compounds, and healthy detox enzyme function.

3. Phase III – Elimination via the Gut and Kidneys

Even the best metabolism doesn’t help if your estrogen is reabsorbed due to poor gut health or sluggish bile flow. EstroProtect helps ensure excreted estrogens stay excreted.

What’s Inside EstroProtect?

Each capsule of EstroProtect includes a synergistic blend of ingredients that address all three phases of estrogen detox:

✔ DIM (Diindolylmethane) – 15 mg

  • Found in cruciferous vegetables

  • Helps shift metabolism to the 2-OH (protective) pathway

  • Supports breast, cervical, and uterine tissue health

✔ Calcium D-Glucarate – 100 mg

  • Prevents estrogen reabsorption in the gut

  • Inhibits β-glucuronidase, an enzyme that can reverse detoxification

  • Especially useful if you have gut dysbiosis

✔ Broccoli Seed Extract (Sulforaphane) – 4.5 mg

  • Activates phase II detoxification enzymes (via Nrf2 pathway)

  • Supports liver function and antioxidant defense

✔ Green Tea Extract (EGCG) – 50 mg

  • Supports healthy estrogen metabolism

  • Antioxidant-rich and may lower 4-OH and 16-OH estrogens

✔ Methylated B Vitamins

  • B6 (P-5-P), B12 (Methylcobalamin), Folate (5-MTHF)

  • Essential for methylation of estrogen metabolites

  • Especially helpful for individuals with MTHFR or COMT SNPs

✔ Trans-Resveratrol – 20 mg

  • Anti-inflammatory and antioxidant

  • May help reduce aromatase activity (conversion of androgens to estrogens)

Lab Testing to Pair With EstroProtect

For a tailored approach, consider working with a practitioner who can order functional lab testing. These tests help identify how well your body is metabolizing estrogen and guide optimal dosing and duration for EstroProtect:

  • HUMAP Hormone Panel
    Measures estrogen metabolites (2-OH, 4-OH, 16α-OH) and methylation markers to assess your detox pathways.

  • Comprehensive Stool Analysis
    Evaluates gut health and levels of beta-glucuronidase, a bacterial enzyme that can cause estrogen reabsorption.

  • MTHFR, COMT, and GST Gene Tests
    Reveal genetic tendencies that affect methylation, detoxification, and estrogen clearance.

  • Liver Function and Bile Acid Panels
    Assess phase I and II detox capacity and bile flow—critical for hormone and toxin elimination.

These tests don’t just explain why estrogen may be imbalanced—they help track your progress and optimize your supplement routine over time.

Who Can Benefit from EstroProtect?

EstroProtect is formulated for anyone looking to support healthy estrogen clearance—whether you're producing too much estrogen, not detoxifying it efficiently, or reabsorbing it due to gut issues.

Ideal for:

  • Women with PMS, fibroids, endometriosis, or painful periods

  • Men with estrogen dominance or low testosterone

  • Perimenopausal or menopausal women managing hormone shifts

  • Individuals with MTHFR or COMT gene variants

  • People exposed to xenoestrogens (plastics, pesticides, cosmetics)

If you’re on hormone therapy (BHRT), supporting detox with a formula like this can help keep hormone metabolites balanced and non-reactive.

EstroProtect vs. Basic DIM Formulas

While DIM is a popular ingredient in hormone support supplements, using DIM alone is often not enough. EstroProtect stands out because it also supports:

  • Methylation with active B vitamins

  • Gut clearance with calcium D-glucarate

  • Liver detox pathways with sulforaphane and green tea

  • Hormone-sensitive tissues with antioxidant protection

It’s a comprehensive formula designed for all three phases of estrogen detox—not just one.

How to Take EstroProtect

  • Suggested Use: 2 capsules daily with food

  • Best taken: In the morning or with lunch to support daily detox rhythms

  • Important: Always consult your healthcare provider if you're pregnant, breastfeeding, or on hormone therapy or medications.

Final Thoughts

Estrogen balance isn’t just about how much estrogen you make—it’s about how well your body processes and eliminates it. Supporting that process reduces the risk of hormone-driven symptoms and conditions while promoting clear skin, better energy, improved mood, and smoother cycles.

If you're navigating hormonal imbalance or looking for preventive hormone support, EstroProtect offers a research-based, physician-formulated solution that covers all the critical angles.