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May 11, 2025

Melanotan II Peptide: Tanning, Immunity, and Metabolic Support

Melanotan II offers benefits for skin pigmentation, immune modulation, and appetite control. Discover dosing strategies and physician-supervised use.

Melanotan II Peptide for tanning, immunity, metabolic support

Melanotan II Peptide Therapy: Beyond Tanning—Immunity, Metabolism, and Wellness Support

Most people recognize Melanotan II as a “tanning peptide,” but there’s so much more beneath the surface. Originally developed for UV protection, Melanotan II has since been shown to provide powerful effects on immunity, metabolism, appetite regulation, and sexual function.

At Revolution Health & Wellness, we offer physician-supervised Melanotan II protocols tailored not only for safe tanning, but also for immune support and metabolic enhancement. With careful dosing, clinical oversight, and peptide purity, this multifaceted therapy is becoming a favorite in advanced functional medicine protocols.

What is Melanotan II?

Melanotan II is a synthetic analog of alpha-Melanocyte Stimulating Hormone (α-MSH). It was developed to mimic the action of naturally occurring MSH, a hormone involved in:

  • Melanin production (skin pigmentation)

  • Immune system modulation

  • Appetite regulation

  • Sexual arousal and libido

  • Inflammatory balance

Melanotan II works by binding to melanocortin receptors (MC1R, MC3R, MC4R, and MC5R), which are found not only in the skin but also in the brain, immune system, gut, and sexual organs.

Key Benefits of Melanotan II Peptide

1. Skin Pigmentation and UV Protection

Melanotan II enhances melanin production, allowing for a darker, more even tan with significantly less UV exposure. It is particularly useful for:

  • Fair-skinned individuals who burn easily

  • Those with photosensitivity disorders (e.g., lupus)

  • Patients wishing to reduce sun damage or avoid artificial tanning

2. Appetite and Weight Management

By acting on MC4R receptors, Melanotan II suppresses appetite, improves satiety, and may support weight loss or metabolic reset, particularly in:

  • Patients with insulin resistance

  • Those with cravings or binge tendencies

  • Individuals starting peptide-based weight loss protocols

3. Immune Modulation

Melanotan II modulates inflammatory pathways and cytokine production, offering immune support in:

  • Autoimmune disease

  • Histamine intolerance or MCAS

  • Viral reactivation (EBV, CMV)

  • Seasonal immune enhancement

4. Neuroprotection and Brain Inflammation

Emerging evidence shows α-MSH analogs like Melanotan II reduce neuroinflammation, enhance brain-derived neurotrophic factor (BDNF), and may support cognitive health in:

  • Long COVID

  • Brain fog

  • Post-viral syndromes

  • Early neurodegenerative states

5. Enhanced Libido and Erectile Function

Due to its action on the central melanocortin system, Melanotan II is also known for:

  • Boosting libido in men and women

  • Improving erectile function in ED

  • Supporting sexual health without hormonal disruption

How Melanotan II Works: Mechanism of Action

Melanotan II activates multiple melanocortin receptors (MC1R–MC5R), each responsible for different physiological effects:

  • MC1R – Stimulates melanin production in the skin

  • MC3R & MC4R – Regulate appetite, energy homeostasis, and inflammation

  • MC5R – Influences exocrine gland secretion, libido, and skin repair

  • CNS effects – Reduces oxidative stress, enhances mood and libido

These systemic effects give Melanotan II its broad therapeutic range.

Reconstitution and Dosing Instructions

Each Melanotan II vial contains:

  • 10mg of peptide powder

To reconstitute:

  • Add 2.5mL of sterile or bacteriostatic water

  • This creates a solution of 0.004mg (4mcg) per unit

Melanotan II Protocols

We offer three clinically distinct protocols based on intended use.

1. Tanning Protocol

Phase 1 – Initiation

  • Dose: 0.2mg (5 units) SubQ daily

  • Duration: 5 days

Phase 2 – Intensification

  • Dose: 0.3mg (7.5 units) SubQ daily

  • Duration: 5 days

Phase 3 – Maintenance

  • Dose: 0.5mg (10 units) SubQ twice weekly

  • Duration: Ongoing for maintenance or seasonal use

Notes:

  • Use low-level UV exposure during initiation phase to stimulate even pigmentation

  • Ideal for fair-skinned individuals seeking gradual, natural-looking tan

  • Reduce dose if experiencing nausea or darkening of moles

2. Immune Support Protocol

  • Dose: 0.2mg (5 units) SubQ daily

  • Duration: 6–8 weeks

Ideal for:

  • Autoimmune modulation

  • Histamine intolerance or seasonal allergies

  • Viral suppression (EBV, HSV, CMV)

  • Immune resiliency pre/post-travel

3. Metabolic Support Protocol

  • Dose: 0.05mg (1.25 units) SubQ daily

  • Duration: 4–8 weeks or as part of a weight-loss plan

Ideal for:

  • Appetite suppression

  • Sugar craving reduction

  • Pairing with GLP-1 medications or MOTS-c

Who Should Consider Melanotan II?

Melanotan II may benefit individuals who are:

  • Seeking safer tanning without UV overexposure

  • Living with autoimmune or inflammatory disorders

  • Experiencing cravings or metabolic dysregulation

  • Recovering from post-viral or inflammatory states

  • Desiring enhanced libido or sexual performance

Side Effects and Considerations

Common (Dose-dependent):

  • Nausea (usually transient; take at night or reduce dose)

  • Flushing or facial warmth

  • Appetite suppression (desired in some cases)

  • Fatigue or dizziness (rare)

Less Common:

  • Darkening of freckles or moles (especially in fair-skinned users)

  • Hyperpigmentation of scars or birthmarks

  • Spontaneous erections (especially in males at higher doses)

Contraindications:

  • History of melanoma or atypical nevi

  • Active hormone-sensitive cancers

  • Uncontrolled autoimmune flares without provider oversight

Clinical Case Examples

Case 1: Safe Tanning and Photosensitivity

A 30-year-old female with light skin and lupus-associated photosensitivity followed the tanning protocol.

  • Outcome: Achieved moderate tan within 10 days

  • Maintenance: 0.5mg twice weekly + limited UV exposure

  • Result: Fewer rashes and improved skin confidence

Case 2: Appetite Suppression in Obesity

A 48-year-old male with metabolic syndrome struggled with sugar cravings and late-night snacking.

  • Protocol: 0.05mg daily (1.25 units) for 6 weeks

  • Adjuncts: Omega 1300, B12 & Folate, MOTS-c

  • Results: 8 lb fat loss, 2-inch waist reduction, improved satiety

Case 3: Immune Flare and HSV Reactivation

A 41-year-old woman with recurrent HSV flares and low immune function used Melanotan II 0.2mg daily.

  • Duration: 8 weeks, combined with KPV

  • Results: No viral flares during protocol; improved energy and immune balance

Combining Melanotan II with Other Peptides

Melanotan II pairs well with:

How Our Peptides Are Different

At Revolution Health & Wellness, we offer:

  • Pharmaceutical-grade Melanotan II

  • Sourced from FDA-inspected manufacturing facilities

  • Prepared only for physician-supervised patient use

  • No “research chemicals,” no gray-market products

  • Personalized support, education, and safety protocols

Important Legal and Safety Disclaimers

Melanotan II:

  • Is not FDA-approved for any medical condition

  • Is intended for research and educational purposes only

  • Must be used only under physician supervision

  • Is available only to current patients of our clinic

Protocols provided here are for informational purposes only and should not be followed without medical guidance.

Frequently Asked Questions

How long does it take for Melanotan II to produce a tan?

Most users see darkening within 7–10 days, especially with some UV exposure. Full effects within 3–4 weeks.

Can I use this if I already tan easily?

Yes, but lower doses may suffice. Avoid over-darkening or mole discoloration.

Is it safe for long-term use?

Intermittent use is generally safe under supervision. We do not recommend continuous long-term dosing without physician oversight.

Is it legal to purchase Melanotan II online?

Online products are often mislabeled or contaminated. We strongly advise against purchasing from unregulated “research” websites.

Conclusion: Melanotan II—More Than a Tanning Peptide

Melanotan II offers unique value as a multifaceted peptide—supporting skin tone, immune resilience, appetite regulation, and sexual health. With proper supervision, this therapy may help you look and feel better—from the inside out.

Get Started with Melanotan II Today

📞 Call the clinic to schedule your consultation
🌐 Learn more or become a patient at RevolutionHealth.org

Scientific References

  1. Wessells H et al. “Melanocortin receptor agonists and erectile function.” J Urol. 2000.

  2. Hadley ME. “Melanocortin peptides and their receptors: from MSH to MC1R.” Endocr Rev. 1999.

  3. Ezzat S et al. “Melanotan II peptide: metabolism and appetite regulation.” Peptides. 2008.

  4. Brzoska T et al. “Melanocortins in skin and systemic anti-inflammatory activity.” Pharmacol Ther. 2008.

  5. Lindqvist A et al. “Role of melanocortin system in energy balance and immune response.” J Intern Med. 2005.